Multiple clinical episodes of Plasmodium falciparum malaria in a low transmission intensity setting: exposure versus immunity

@inproceedings{Rono2015MultipleCE,
  title={Multiple clinical episodes of Plasmodium falciparum malaria in a low transmission intensity setting: exposure versus immunity},
  author={Josea Rono and Anna F{\"a}rnert and Linda Muthoni Murungi and John Ojal and Gathoni Kamuyu and Fatuma Guleid and George M. Nyangweso and Juliana Wambua and Barnes S Kitsao and Ally Ibrahim Olotu and Kevin Marsh and Faith H. A. Osier},
  booktitle={BMC medicine},
  year={2015}
}
BackgroundEpidemiological studies indicate that some children experience many more episodes of clinical malaria than their age mates in a given location. Whether this is as a result of the micro-heterogeneity of malaria transmission with some children effectively getting more exposure to infectious mosquitoes than others, or reflects a failure in the acquisition of immunity needs to be elucidated. Here, we investigated the determinants of increased susceptibility to clinical malaria by… CONTINUE READING
BETA
10
Twitter Mentions

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES

Breadth of anti-merozoite antibody responses is associated with the genetic diversity of asymptomatic Plasmodium falciparum infections and protection against clinical malaria.

  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2013
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL