Multiple cis-acting signals for export of pre-U1 snRNA from the nucleus.

@article{Terns1993MultipleCS,
  title={Multiple cis-acting signals for export of pre-U1 snRNA from the nucleus.},
  author={Michael P Terns and J. E. Dahlberg and Elsebet Lund},
  journal={Genes & development},
  year={1993},
  volume={7 10},
  pages={1898-908}
}
We have identified cis-acting sequences that promote nuclear export of pre-U1 RNA injected into Xenopus oocyte nuclei. At least three elements, the 5' m7G cap, the 3'-terminal stem-loop structure, and sequences in the 5'-terminal 124 nucleotides, contribute to efficient export of this RNA. Both the 5' and 3' export signals can function separately and do so independently of the cap structure. Experiments using hybrid RNAs indicate that the 5' and 3' export sequences of U1 RNA are sufficient to… CONTINUE READING

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