Multiple changes in sialic acid biology during human evolution

@article{Varki2008MultipleCI,
  title={Multiple changes in sialic acid biology during human evolution},
  author={Ajit Varki},
  journal={Glycoconjugate Journal},
  year={2008},
  volume={26},
  pages={231-245}
}
Humans are genetically very similar to “great apes”, (chimpanzees, bonobos, gorillas and orangutans), our closest evolutionary relatives. We have discovered multiple genetic and biochemical differences between humans and these other hominids, in relation to sialic acids and in Siglecs (Sia-recognizing Ig superfamily lectins). An inactivating mutation in the CMAH gene eliminated human expression of N-glycolylneuraminic acid (Neu5Gc) a major sialic acid in “great apes”. Additional human-specific… CONTINUE READING

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Humans are genetically very similar to “ great apes ” , ( chimpanzees , bonobos , gorillas and orangutans ) , our closest evolutionary relatives .
Humans are genetically very similar to “ great apes ” , ( chimpanzees , bonobos , gorillas and orangutans ) , our closest evolutionary relatives .
Humans are genetically very similar to “ great apes ” , ( chimpanzees , bonobos , gorillas and orangutans ) , our closest evolutionary relatives .
Humans are genetically very similar to “ great apes ” , ( chimpanzees , bonobos , gorillas and orangutans ) , our closest evolutionary relatives .
Humans are genetically very similar to “ great apes ” , ( chimpanzees , bonobos , gorillas and orangutans ) , our closest evolutionary relatives .
Humans are genetically very similar to “ great apes ” , ( chimpanzees , bonobos , gorillas and orangutans ) , our closest evolutionary relatives .
Humans are genetically very similar to “ great apes ” , ( chimpanzees , bonobos , gorillas and orangutans ) , our closest evolutionary relatives .
Humans are genetically very similar to “ great apes ” , ( chimpanzees , bonobos , gorillas and orangutans ) , our closest evolutionary relatives .
Humans are genetically very similar to “ great apes ” , ( chimpanzees , bonobos , gorillas and orangutans ) , our closest evolutionary relatives .
Humans are genetically very similar to “ great apes ” , ( chimpanzees , bonobos , gorillas and orangutans ) , our closest evolutionary relatives .
Humans are genetically very similar to “ great apes ” , ( chimpanzees , bonobos , gorillas and orangutans ) , our closest evolutionary relatives .
Humans are genetically very similar to “ great apes ” , ( chimpanzees , bonobos , gorillas and orangutans ) , our closest evolutionary relatives .
PongidaeNo subtypePongo
Humans are genetically very similar to “ great apes ” , ( chimpanzees , bonobos , gorillas and orangutans ) , our closest evolutionary relatives .
PongoNo subtypePongidae
Humans are genetically very similar to “ great apes ” , ( chimpanzees , bonobos , gorillas and orangutans ) , our closest evolutionary relatives .
Humans are genetically very similar to “ great apes ” , ( chimpanzees , bonobos , gorillas and orangutans ) , our closest evolutionary relatives .
Humans are genetically very similar to “ great apes ” , ( chimpanzees , bonobos , gorillas and orangutans ) , our closest evolutionary relatives .
We have discovered multiple genetic and biochemical differences between humans and these other hominids , in relation to sialic acids and in Siglecs ( Sia - recognizing Ig superfamily lectins ) .
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