Multiple biomarkers for the prediction of first major cardiovascular events and death.

  title={Multiple biomarkers for the prediction of first major cardiovascular events and death.},
  author={Thomas J. Wang and Philimon N. Gona and Martin G. Larson and Geoffrey H Tofler and Daniel Levy and Christopher Newton-Cheh and Paul F. Jacques and Nader Rifai and Jacob Selhub and Sander J. Robins and Emelia J. Benjamin and Ralph B. D'Agostino and Ramachandran S. Vasan},
  journal={The New England journal of medicine},
  volume={355 25},
BACKGROUND Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting the risk of cardiovascular events. METHODS We measured 10 biomarkers in 3209 participants attending a routine examination cycle of the Framingham Heart Study: the levels of C-reactive protein, B-type natriuretic peptide, N-terminal pro-atrial natriuretic peptide, aldosterone, renin, fibrinogen, D-dimer, plasminogen-activator inhibitor type 1, and… 

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