Multiple biological predictors for vulnerable carotid lesions.

  title={Multiple biological predictors for vulnerable carotid lesions.},
  author={Jaroslav Pelisek and Martina Rudelius and Peter Zepper and Holger Poppert and Christian Reeps and Tibor Schuster and Hans-Henning Eckstein},
  journal={Cerebrovascular diseases},
  volume={28 6},
BACKGROUND In this study a multiscore analysis of various biomarkers including matrix metalloproteinases (MMPs), inflammatory factors and other clinical parameters was performed to establish a set of reliable biomarkers for improved detection of plaque instability in patients with advanced carotid stenosis. METHODS Study patients (n = 101) were classified as histologically stable (n = 37) or unstable (n = 64). Serum levels of MMP-1, -2, -3, -7, -8, -9, MMP inhibitors TIMP-1, -2, and… CONTINUE READING
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