Multiple binding of methyl-CpG and polycomb proteins in long-term gene silencing events.

@article{Matarazzo2007MultipleBO,
  title={Multiple binding of methyl-CpG and polycomb proteins in long-term gene silencing events.},
  author={Maria R Matarazzo and Maria Luigia De Bonis and Maria Strazzullo and Andrea Cerase and M Ferraro and Paola Vastarelli and Esteban Ballestar and Manel Esteller and Susumu Kudo and Maurizio D'Esposito},
  journal={Journal of cellular physiology},
  year={2007},
  volume={210 3},
  pages={
          711-9
        }
}
Epigenetic regulation is involved in the maintenance of long-term silencing phenomena, such as X-inactivation and genomic imprinting in mammals. Gene repression is mediated by several mechanisms, such as histone modifications, DNA methylation, and recruitment of Polycomb proteins. To understand the mechanistic relationships between these mechanisms for stable gene silencing, we analyzed the mechanisms of X- and Y-inactivation of the PAR2 gene SYBL1, previously showed to be regulated by… CONTINUE READING

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