Multiple binding modes of the camptothecin family to DNA oligomers.

@article{Bocian2004MultipleBM,
  title={Multiple binding modes of the camptothecin family to DNA oligomers.},
  author={Wojciech Bocian and Robert Kawęcki and Elżbieta Bednarek and Jerzy Sitkowski and A Pietrzyk and Michael P Williamson and Poul Erik Hansen and Lech Kozerski},
  journal={Chemistry},
  year={2004},
  volume={10 22},
  pages={5776-87}
}
The binding constants of camptothecin, topotecan and its lactone ring-opened carboxylate derivative to DNA octamers were measured by UV and NMR spectroscopy. The self-association of topotecan (TPT) was also measured. The carboxylate form of TPT binds in the same way as the lactone, but more weakly. Titration of TPT into d(GCGATCGC)2 shows a preferred location stacked onto the terminal G1 base. However, the intermolecular NOEs cannot be reconciled with a single conformation of the complex, and… CONTINUE READING

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