Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II.

@article{Itoh1993MultipleAG,
  title={Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II.},
  author={Hiroshi Itoh and Masashi Mukoyama and Richard E. Pratt and Gary H. Gibbons and V J Dzau},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={91 5},
  pages={2268-74}
}
Angiotensin (Ang) II stimulates hypertrophic growth of vascular smooth muscle cells (VSMC). Accompanying this growth is the induction of the expression of growth-related protooncogenes (c-fos, c-jun, and c-myc), as well as the synthesis of the autocrine growth factors, such as PDGF-A and TGF-beta 1. In this study, we demonstrate further that Ang II also induces the synthesis of basic fibroblast growth factor (bFGF), a potent mitogen for VSMC. To examine how these factors interact to modulate… CONTINUE READING
146 Citations
30 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 146 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Role of TGF - fl activation in the cellular growth to Ang II

  • I. Vlodavsky, R. Fridman, R. Sullivan, J. Sasse, M. Klagsbrun
  • 1993

Antisense oligonucleotides complementary to PDGF mRNA attenuate angiotensin II - induced vascular hypertrophy

  • D. Danielpour, L. L. Dart, K. C. Flanders, A. B. Roberts, M. B. Sporn
  • Hypertension ( Dallas ) .
  • 1990

Similar Papers

Loading similar papers…