Multiple atherosclerosis-related biomarkers associated with short- and long-term mortality after stroke.

Abstract

OBJECTIVES We investigated the relationships of biomarkers of various pathophysiologic pathways including high-sensitivity C-reactive protein (hs-CRP), lipocalin-2 (LCN2), myeloperoxidase (MPO) and matrix metalloproteinases 9 (MMP9) with mortality in stroke patients. DESIGN AND METHODS hs-CRP, LCN2 and MPO concentrations in 92 patients were determined using enzyme-linked immunosorbent assays. MMP9 mRNA concentrations were determined using real-time quantitative reverse transcription-polymerase chain reaction. RESULTS Twelve patients (13.0%) died at 6 months and 34 patients (37.0%) died at 5 years. The independent predictors for 6-month mortality were hs-CRP (adjusted OR=16.0) and LCN2 (adjusted OR=16.9), while for 5-year mortality was hs-CRP (adjusted OR=5.56). For patients with hs-CRP >3.4 mg/L, an increase in LCN2 was associated with 2.5-fold higher 6-month mortality, while an increase in normalized MMP9 mRNA was associated with 5.8-fold higher 6-month and 1.5-fold higher 5-year mortality. CONCLUSION hs-CRP was the most significant independent predictor of both short- and long-term mortality after stroke, with LCN2 and MMP9 mRNA each adding further to the risk stratification.

DOI: 10.1016/j.clinbiochem.2012.06.014

Cite this paper

@article{Chan2012MultipleAB, title={Multiple atherosclerosis-related biomarkers associated with short- and long-term mortality after stroke.}, author={Cangel Pui-yee Chan and Hui-lin Jiang and Ling-yan Leung and Wai-man Wan and Nga-man Cheng and Wai-sze Ip and Kwan-yee Cheung and Rebecca Wing-yan Chan and Lawrence Wong and Colin A. Graham and Reinhard Renneberg and Timothy Hudson Rainer}, journal={Clinical biochemistry}, year={2012}, volume={45 16-17}, pages={1308-15} }