Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinoma.


BACKGROUND Human hepatocellular carcinoma (HCC) is associated with increased expression and activity of mitogen-activated protein kinase (MAPK) signaling intermediates (ie, MEK, ERK). STUDY DESIGN We determined the effects of MEK-ERK signaling on proliferation, cell cycle, apoptosis, and tumorigenicity of HCC in vitro. HCC cell lines were treated with MEK… (More)