Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast.

  title={Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast.},
  author={Erica L Dahl and Philip J. Rosenthal},
  journal={Antimicrobial agents and chemotherapy},
  volume={51 10},
Several classes of antibiotics exert antimalarial activity. The mechanisms of action of antibiotics against malaria parasites have been unclear, and prior studies have led to conflicting results, in part because they studied antibiotics at suprapharmacological concentrations. We examined the antimalarial effects of azithromycin, ciprofloxacin, clindamycin, doxycycline, and rifampin against chloroquine-resistant (W2) and chloroquine-sensitive (3D7) Plasmodium falciparum strains. At clinically… CONTINUE READING


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