Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast.

@article{Dahl2007MultipleAE,
  title={Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast.},
  author={Erica L Dahl and Philip J. Rosenthal},
  journal={Antimicrobial agents and chemotherapy},
  year={2007},
  volume={51 10},
  pages={3485-90}
}
Several classes of antibiotics exert antimalarial activity. The mechanisms of action of antibiotics against malaria parasites have been unclear, and prior studies have led to conflicting results, in part because they studied antibiotics at suprapharmacological concentrations. We examined the antimalarial effects of azithromycin, ciprofloxacin, clindamycin, doxycycline, and rifampin against chloroquine-resistant (W2) and chloroquine-sensitive (3D7) Plasmodium falciparum strains. At clinically… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 99 extracted citations

Reliability of antimalarial sensitivity tests depends on drug mechanisms of action.

Journal of clinical microbiology • 2010
View 6 Excerpts
Highly Influenced

Targeting apicoplasts in malaria parasites.

Expert opinion on therapeutic targets • 2013
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…