Multiple anti-interferon actions of the influenza A virus NS1 protein.

@article{Kochs2007MultipleAA,
  title={Multiple anti-interferon actions of the influenza A virus NS1 protein.},
  author={Georg Kochs and Adolfo Garc{\'i}a-Sastre and Luis Mart{\'i}nez-Sobrido},
  journal={Journal of virology},
  year={2007},
  volume={81 13},
  pages={7011-21}
}
The replication and pathogenicity of influenza A virus (FLUAV) are controlled in part by the alpha/beta interferon (IFN-alpha/beta) system. This virus-host interplay is dependent on the production of IFN-alpha/beta and on the capacity of the viral nonstructural protein NS1 to counteract the IFN system. Two different mechanisms have been described for NS1, namely, blocking the activation of IFN regulatory factor 3 (IRF3) and blocking posttranscriptional processing of cellular mRNAs. Here we… CONTINUE READING
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