Multiple anomalies in a fetus exposed to low-dose methotrexate in the first trimester.

@article{Nguyen2002MultipleAI,
  title={Multiple anomalies in a fetus exposed to low-dose methotrexate in the first trimester.},
  author={Christine Nguyen and Adam J. Duhl and Cathleen S Escallon and Karin J. Blakemore},
  journal={Obstetrics and gynecology},
  year={2002},
  volume={99 4},
  pages={
          599-602
        }
}
BACKGROUND Methotrexate has multiple therapeutic uses in women of reproductive age including treatment for ectopic pregnancy, neoplastic disease, autoimmune disorders, and inflammatory conditions. More frequent use of methotrexate may result in an increased number of exposures in pregnant women and their fetuses. CASE A 16-year-old gravida 1, para 0 used oral methotrexate treatment of 7.5 mg per day for psoriasis for 2 days at 3.5 weeks postconception. Multiple anomalies were noted on an 18… CONTINUE READING
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