Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

@article{Saharinen2005MultipleAR,
  title={Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2},
  author={Pipsa Saharinen and Katja Kerkel{\"a} and Niklas Ekman and Marie B Marron and Nicholas P. J. Brindle and Gyun Min Lee and Hellmut G Augustin and Gou Young Koh and Kari Alitalo},
  journal={The Journal of Cell Biology},
  year={2005},
  volume={169},
  pages={239 - 243}
}
The Tie1 receptor tyrosine kinase was isolated over a decade ago, but so far no ligand has been found to activate this receptor. Here, we have examined the potential of angiopoietins, ligands for the related Tie2 receptor, to mediate Tie1 activation. We show that a soluble Ang1 chimeric protein, COMP-Ang1, stimulates Tie1 phosphorylation in endothelial cells with similar kinetics and angiopoietin dose dependence when compared with Tie2. The phosphorylation of overexpressed Tie1 was weakly… CONTINUE READING
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