Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP.

@article{Sun2007MultipleAS,
  title={Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP.},
  author={Zhe Sun and Frank Anderl and Kathrin Sophie Fr{\"o}hlich and Liyun Zhao and Stefan Hanke and Britta Bruegger and Felix Theodor Wieland and Julien B{\'e}thune},
  journal={Traffic},
  year={2007},
  volume={8 5},
  pages={
          582-93
        }
}
The small GTPase ADP-ribosylation factor-1 (Arf1) plays a key role in the formation of coat protein I (COP I)-coated vesicles. Upon recruitment to the donor Golgi membrane by interaction with dimeric p24 proteins, Arf1's GDP is exchanged for GTP. Arf1-GTP then dissociates from p24, and together with other Golgi membrane proteins, it recruits coatomer, the heptameric coat protein complex of COP I vesicles, from the cytosol. In this process, Arf1 was shown to specifically interact with the… CONTINUE READING
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