Multiple and ancient origins of the domestic dog.

  title={Multiple and ancient origins of the domestic dog.},
  author={Carles Vil{\`a} and Peter Savolainen and Jes{\'u}s E. Maldonado and Isabel R. Amorim and Jessica E. Rice and Rodney L. Honeycutt and Keith A. Crandall and Joakim Lundeberg and Robert K. Wayne},
  volume={276 5319},
Mitochondrial DNA control region sequences were analyzed from 162 wolves at 27 localities worldwide and from 140 domestic dogs representing 67 breeds. Sequences from both dogs and wolves showed considerable diversity and supported the hypothesis that wolves were the ancestors of dogs. Most dog sequences belonged to a divergent monophyletic clade sharing no sequences with wolves. The sequence divergence within this clade suggested that dogs originated more than 100,000 years before the present… 
Genetic Evidence for an East Asian Origin of Domestic Dogs
A larger genetic variation in East Asia than in other regions and the pattern of phylogeographic variation suggest an East Asian origin for the domestic dog, ∼15,000 years ago.
Ancient DNA Evidence for Old World Origin of New World Dogs
Mitochondrial DNA sequences isolated from ancient dog remains from Latin America and Alaska showed that native American dogs originated from multiple Old World lineages of dogs that accompanied late
Ancient DNA Analysis Affirms the Canid from Altai as a Primitive Dog
Analysis of ancient DNA from the recently described putative 33,000-year old Pleistocene dog from Altai reveals that the unique haplotype of the Altai dog is more closely related to modern dogs and prehistoric New World canids than it is to contemporary wolves.
Forensic Utility of the Mitochondrial Hypervariable Region 1 of Domestic Dogs, in Conjunction with Breed and Geographic Information *
A 60‐bp variation “hotspot” within the canid HV1 was identified as a potentially valuable molecular tool, particularly for assaying limited or degraded DNA samples.
Phylogenetic relationships, evolution, and genetic diversity of the domestic dog.
The results do not support a New World domestication of dogs nor a close association of the Xoloitzcuintli with other hair-less breeds of dogs, but mitochondrial DNA analysis suggests a more ancient origin of dogs than has been indicated by the fossil record.
Gene flow between wolf and shepherd dog populations in Georgia (Caucasus).
The results of the study suggest that wolf-dog hybridization is a common event in the areas where large livestock guarding dogs are held in a traditional way, and that gene flow between dogs and gray wolves was an important force influencing gene pool of dogs for millennia since early domestication events.
Mitochondrial DNA from prehistoric canids highlights relationships between dogs and South-East European wolves.
A-DNA support for the involvement of European wolves in the origins of the three major dog clades is provided and genetic data suggest multiple independent domestication events.
Mitochondrial DNA Analysis of the Domestic Dog: Control Region Variation Within and Among Breeds
This reference data set has been compiled and validated against the published dog genetic literature with an aim to aid forensic investigations that seek to incorporate mtDNA sequences and SNPs from trace evidence such as dog hair.
Hybridisation between wolves and dogs in Latvia as documented using mitochondrial and microsatellite DNA markers
The results of molecular genetic analyses of 31 wolf samples collected in Latvia from 1997 to 1999, including six pups originated from a litter found in northern Latvia in March 1999, and six wolves showing morphological traits that suggested hybrid origin are reported.


Molecular genetics of the most endangered canid: the Ethiopian wolf Canis simensis
The results suggest that hybridization has occurred between female Ethiopian wolves and male domestic dogs in one population, and recommend immediate captive breeding of Ethiopian wolves to protect their gene pool from dilution and further loss of genetic variability.
Α Natural History of Domesticated Mammals
The geography of domestication, Climatic sequences and archaeological divisions of the Quaternary period, and nomenclature of the domestic mammals are summarized.
  • A. Templeton
  • Biology
    Evolution; international journal of organic evolution
  • 1983
An algorithm of phylogenetic inference that deals more directly with the problem of convergent evolution and statistical inhomogeneity between different restriction enzymes is proposed and non-parametric statistical procedures are presented for testing hypotheses about relative rates of evolution among the various lineages.
Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data.
Application of AMOVA to human mitochondrial DNA haplotype data shows that population subdivisions are better resolved when some measure of molecular differences among haplotypes is introduced into the analysis, and Monte Carlo studies show that site sampling does not fundamentally affect the significance of the molecular variance components.
Simple methods for testing the molecular evolutionary clock hypothesis.
Simple statistical methods for testing the molecular evolutionary clock hypothesis are developed which can be applied to both nucleotide and amino acid sequences and are similar to those of the likelihood ratio test and the relative rate test, in spite of the fact that the latter two tests assume that the pattern of substitution rates follows a certain model.
Identification of immunosuppressive drug targets in yeast
Studies on immunosuppressant mechanisms of action are providing insights into signal transduction in both yeast and T lymphocytes, and the primary drug targets, the immunophilins cyclophilin and FKBP, are highly conserved from yeast to human.
References and Notes
our experimentation could eventually be used to discredit our findings, should they happen not to agree with the original observations. It seems important that all experiments in the rapidly
The Lost History of the Canine Race
  • Love Affair with Dogs (Andrews & McMeel, Kansas City, KS,
  • 1996