Multiple alpha-fetoprotein RNAs in adult rat liver: cell type-specific expression and differential regulation.

@article{Lemire1991MultipleAR,
  title={Multiple alpha-fetoprotein RNAs in adult rat liver: cell type-specific expression and differential regulation.},
  author={Joan M Lemire and Nelson Fausto},
  journal={Cancer research},
  year={1991},
  volume={51 17},
  pages={4656-64}
}
Multiple alpha-fetoprotein (AFP) RNAs are expressed in the rat liver and are differentially regulated during development. We examined the expression and cellular distribution of the full-length AFP RNA (major form, 2.1 kilobases highly expressed in fetal liver) and 3 variants of 1.7, 1.4, and 1.0 kilobases in normal rat liver, during fetal development, in regeneration, and in carcinogenesis. The 1.7-kilobase variant is expressed only in developing liver (by 15 days of gestation) and is much… CONTINUE READING
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