Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the Mdr2-knockout mice.

@article{Katzenellenbogen2006MultipleAM,
  title={Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the Mdr2-knockout mice.},
  author={Mark Katzenellenbogen and Orit Pappo and Hila Barash and Naama Klopstock and Lina Mizrahi and Devorah Olam and Jasmine Jacob-Hirsch and Ninette Amariglio and Gidi Rechavi and Leslie A Mitchell and Ron Kohen and Eytan Domany and Eithan Galun and Daniel S. Goldenberg},
  journal={Cancer research},
  year={2006},
  volume={66 8},
  pages={
          4001-10
        }
}
Molecular events preceding the development of hepatocellular carcinoma were studied in the Mdr2-knockout (Mdr2-KO) mice. These mice lack the liver-specific P-glycoprotein responsible for phosphatidylcholine transport across the canalicular membrane. Portal inflammation ensues at an early age followed by hepatocellular carcinoma development after the age of 1 year. Liver tissue samples of Mdr2-KO mice in the early and late precancerous stages of liver disease were subjected to histologic… CONTINUE READING

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