Multiple actions of extracellular ATP on calcium currents in cultured bovine chromaffin cells.

@article{DiversPierluissi1991MultipleAO,
  title={Multiple actions of extracellular ATP on calcium currents in cultured bovine chromaffin cells.},
  author={Mar{\'i}a A Divers{\'e}-Pierluissi and Kathleen Dunlap and Edward W Westhead},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 4},
  pages={1261-5}
}
Hormone secretion from chromaffin cells is evoked by calcium influx through voltage-dependent channels in the plasma membrane. Previous studies have shown that ATP, cosecreted with catecholamines from chromaffin granules, can modulate the secretion resulting from depolarization by nicotinic agonists. The immediate effect of ATP is to enhance secretion; more prolonged exposure to the nucleotide results in inhibition. These receptor-mediated actions of ATP involve the activation of at least two… CONTINUE READING
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