Multiple abnormalities of myocardial insulin signaling in a porcine model of diet-induced obesity.

@article{Lee2010MultipleAO,
  title={Multiple abnormalities of myocardial insulin signaling in a porcine model of diet-induced obesity.},
  author={Jenny K Lee and Ya Ming Xu and Li Ying Lu and Bryan Christopher Bergman and Jonathan Leitner and Clifford R. Greyson and Boris B Draznin and Gregory G. Schwartz},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2010},
  volume={298 2},
  pages={
          H310-9
        }
}
Heightened cardiovascular risk among patients with systemic insulin resistance is not fully explained by the extent of atherosclerosis. It is unknown whether myocardial insulin resistance accompanies systemic insulin resistance and contributes to increased cardiovascular risk. This study utilized a porcine model of diet-induced obesity to determine if myocardial insulin resistance develops in parallel with systemic insulin resistance and investigated potential mechanisms for such changes… CONTINUE READING

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