Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappaB.

@article{Chen2005MultipleTA,
  title={Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappaB.},
  author={Xiqiang Chen and Steven O'Hara and Jeremy B. Nelson and Patrick L. Splinter and Aaron J Small and Pamela S. Tietz and Andrew H. Limper and Nicholas F. LaRusso},
  journal={Journal of immunology},
  year={2005},
  volume={175 11},
  pages={7447-56}
}
Infection of epithelial cells by Cryptosporidium parvum triggers a variety of host-cell innate and adaptive immune responses including release of cytokines/chemokines and up-regulation of antimicrobial peptides. The mechanisms that trigger these host-cell responses are unclear. Thus, we evaluated the role of TLRs in host-cell responses during C. parvum infection of cultured human biliary epithelia (i.e., cholangiocytes). We found that normal human cholangiocytes express all known TLRs. C… CONTINUE READING

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