Multiple Symmetric Lipomatosis (Madelung's Disease) Caused by the MERRF (A8344G) Mutation: A Report of Two Cases and Review of the Literature.

@article{Chong2003MultipleSL,
  title={Multiple Symmetric Lipomatosis (Madelung's Disease) Caused by the MERRF (A8344G) Mutation: A Report of Two Cases and Review of the Literature.},
  author={Peter Siao Tick Chong and Steven Vucic and E. Tessa Hedley-Whyte and Michael Dreyer and Didier P. Cros},
  journal={Journal of clinical neuromuscular disease},
  year={2003},
  volume={5 1},
  pages={1-7}
}
Multiple symmetric lipomatosis (MSL) was first described by Brodie in 1846 and is characterized by accumulation of non-encapsulated lipomas in the cervical-cranial-thoracic region. Alcohol consumption is regarded as essential in lipoma development by some. Mitochondrial dysfunction was first reported in 1991. Since then, there has been controversy regarding etiology of MSL, with a number of studies supporting and some refuting the role of mitochondrial dysfunction. We report on 2 cases of MSL… CONTINUE READING