Multiple Signaling Pathways Coordinate to Induce a Threshold Response in a Chordate Embryo

@inproceedings{Ohta2013MultipleSP,
  title={Multiple Signaling Pathways Coordinate to Induce a Threshold Response in a Chordate Embryo},
  author={Naoyuki Ohta and Yutaka Satou},
  booktitle={PLoS genetics},
  year={2013}
}
In animal development, secreted signaling molecules evoke all-or-none threshold responses of target gene transcription to specify cell fates. In the chordate Ciona intestinalis, the neural markers Otx and Nodal are induced at early embryonic stages by Fgf9/16/20 signaling. Here we show that three additional signaling molecules act negatively to generate a sharp expression boundary for neural genes. EphrinA signaling antagonizes FGF signaling by inhibiting ERK phosphorylation more strongly in… CONTINUE READING

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