Multiple Sclerosis and the Blood-Central Nervous System Barrier

  • Alan M. Palmer
  • Published 2013 in Cardiovascular psychiatry and neurology

Abstract

The central nervous system (CNS) is isolated from the blood system by a physical barrier that contains efflux transporters and catabolic enzymes. This blood-CNS barrier (BCNSB) plays a pivotal role in the pathophysiology of multiple sclerosis (MS). It binds and anchors activated leukocytes to permit their movement across the BCNSB and into the CNS. Once… (More)
DOI: 10.1155/2013/530356

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