Multiple Sclerosis: Neurofilament Pathology in Spinal Motor Neurons

  title={Multiple Sclerosis: Neurofilament Pathology in Spinal Motor Neurons},
  author={Kathrin S Muller-Wielsch and Barbara Cannella and Cedric S. Raine},
  journal={Journal of multiple sclerosis},
Objective: While traditionally a disorder of myelin, in multiple sclerosis (MS) neuronal and axonal damage has in recent years become an important topic of clinical relevance. To address this, alterations in neurofilament phosphorylation, known markers of neuronal health, were investigated in anterior horn cells in MS spinal cord tissue for signs of motor neuron damage. Methods: Spinal cord tissue was examined from 13 MS and 6 control patients. Fresh frozen sections were labelled with… 
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