Multiple Sclerosis: Mechanisms and Immunotherapy

  title={Multiple Sclerosis: Mechanisms and Immunotherapy},
  author={C. Baecher-Allan and Belinda J. Kaskow and H. Weiner},
  • C. Baecher-Allan, Belinda J. Kaskow, H. Weiner
  • Published 2018
  • Medicine
  • Neuron
  • Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act on a genetically susceptible host. It features three clinical stages: a pre-clinical stage detectable only by MRI; a relapsing-remitting (RRMS) stage characterized by episodes of neurologic dysfunction followed by resolution; and a progressive stage, which usually evolves from the relapsing stage. Advances in our understanding of the immune mechanisms that contribute to MS have led to more than ten FDA… CONTINUE READING
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