Multiple Sclerosis: Current Pathophysiological Concepts

  title={Multiple Sclerosis: Current Pathophysiological Concepts},
  author={Dean M. Wingerchuk and C F Lucchinetti and John H. Noseworthy},
  journal={Laboratory Investigation},
Multiple sclerosis (MS) is an often disabling disease primarily affecting young adults that exhibits extraordinary clinical, radiological, and pathological heterogeneity. We review the following: (a) known environmental and genetic factors that contribute to MS susceptibility; (b) current knowledge regarding fundamental pathophysiological processes in MS, including immune cell recruitment and entry into the central nervous system (CNS), formation of the plaque, and orchestration of the immune… CONTINUE READING
60 Citations
169 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 60 extracted citations


Publications referenced by this paper.
Showing 1-10 of 169 references

Humoral mechanisms in the pathogenesis of Devic’s neuromyelitis optica

  • C Lucchinetti, R Mandler, B Weinshenker, D Wingerchuk, J Parisi, H Lassmann
  • (Abstr) Neurology 54(Suppl 3):A259–260.
  • 2000
Highly Influential
8 Excerpts

Similar Papers

Loading similar papers…