Multiple Sclerosis: Current Pathophysiological Concepts

@article{Wingerchuk2001MultipleSC,
  title={Multiple Sclerosis: Current Pathophysiological Concepts},
  author={Dean M. Wingerchuk and C F Lucchinetti and John H. Noseworthy},
  journal={Laboratory Investigation},
  year={2001},
  volume={81},
  pages={263-281}
}
Multiple sclerosis (MS) is an often disabling disease primarily affecting young adults that exhibits extraordinary clinical, radiological, and pathological heterogeneity. We review the following: (a) known environmental and genetic factors that contribute to MS susceptibility; (b) current knowledge regarding fundamental pathophysiological processes in MS, including immune cell recruitment and entry into the central nervous system (CNS), formation of the plaque, and orchestration of the immune… CONTINUE READING
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Humoral mechanisms in the pathogenesis of Devic’s neuromyelitis optica

  • C Lucchinetti, R Mandler, B Weinshenker, D Wingerchuk, J Parisi, H Lassmann
  • (Abstr) Neurology 54(Suppl 3):A259–260.
  • 2000
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