Multiple Sclerosis: An Overview of Clinical Features, Pathophysiology, Neuroimaging, and Treatment Options

@article{Minagar2014MultipleSA,
  title={Multiple Sclerosis: An Overview of Clinical Features, Pathophysiology, Neuroimaging, and Treatment Options},
  author={Alireza Minagar},
  journal={Colloquium Series on Integrated Systems Physiology: From Molecule To Function},
  year={2014},
  volume={6},
  pages={1-117}
}
  • A. Minagar
  • Published 9 September 2014
  • Biology, Psychology, Medicine
  • Colloquium Series on Integrated Systems Physiology: From Molecule To Function
Abstract Download Free Sample Multiple sclerosis [MS] is one of the most common auto-immune-mediated diseases of the human central nervous system [CNS] which affects young adults and usually causes significant neurological disability. Currently, the causes of MS are still unclear, a cure for MS remains elusive and the effectiveness of treatment varies significantly among individuals. Clinical features and neurological deficits stemming from this progressive neurological disease are diverse… 
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References

SHOWING 1-10 OF 293 REFERENCES
Immunology of Multiple Sclerosis.
TLDR
MS-related factors such as localization of lesions, vulnerability of oligodendrocytes, neurons/axons, and secondary metabolic changes all play a role in the heterogeneous expression of the disease, including different pathologic lesion patterns, neuroimaging findings, disease courses, and severity and response to treatment.
Approaches to neuroprotective strategies in multiple sclerosis
TLDR
MS has a long-term course of accumulating deficit in which neuroinflammation evolves into neurodegeneration, which require different treatment strategies – immune modulation and neuroprotection.
Inflammatory demyelination is not central to the pathogenesis of multiple sclerosis
TLDR
Previously considered to be caused by an autoimmune process mainly affecting myelin and oligodendrocytes in the white matter, recent data provide evidence that a generalized, diffuse neurodegenerative process plays an important role in the pathogenesis of MS.
Axonal transection in the lesions of multiple sclerosis.
TLDR
Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.
Urinary tract infection in multiple sclerosis: a practical algorithm for a common problem
TLDR
A dipstick algorithm based on utilizing urinary dipstick testing allows for more rapid and safer management of UTIs in MS patients with acute relapses and assists them to reach diagnostic decisions and select the appropriate therapy earlier in the course of MS relapse.
Spread of T lymphocyte immune responses to myelin epitopes with duration of multiple sclerosis.
TLDR
The data support the notion that the T cell response in MS broadens with time and is thus implicated in the ongoing pathogenic process, but there was no clear correlation between disease severity and number of epitopes recognized.
Th17 Cell, the New Player of Neuroinflammatory Process in Multiple Sclerosis
TLDR
The majority of knowledge about the role of Th17 in MS pathogenesis is resulted in investigation into EAE animal models, and it is expected that Th17 cell to be as a potent pathogenic factor in disease immunopathophysiology.
The Role of Alpha-4 Integrin in the Aetiology of Multiple Sclerosis
TLDR
The demonstration that selective modulation (blocking) of the adhesion molecule VLA-4 by natalizumab in MS, resembling that observed in experimental disease, represents a major advance in rational therapy.
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