Multiple Roles of the p75 Neurotrophin Receptor in the Nervous System

  title={Multiple Roles of the p75 Neurotrophin Receptor in the Nervous System},
  author={Y X Chen and Jican Zeng and X. Wang and Guanfeng Yao and W. Wang and Wei-Feng Qi and Kyung Yup Kong},
  journal={Journal of International Medical Research},
  pages={281 - 288}
  • Y. Chen, J. Zeng, K. Kong
  • Published 1 March 2009
  • Biology
  • Journal of International Medical Research
The p75 neurotrophin receptor (p75NTR) is a transmembrane protein that binds nerve growth factor (NGF) and has multiple functions in the nervous system where it is expressed widely during the developmental stages of life, although expression decreases dramatically by adulthood. Expression of p75NTR can increase in pathological states related to neural cell death. p75NTR is a member of the tumour necrosis factor (TNF) receptor family and it consists of intracellular, transmembrane and… 
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Induction of cell death by endogenous nerve growth factor through its p75 receptor
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p75 Neurotrophin Receptor Expression on Adult Human Oligodendrocytes: Signaling without Cell Death in Response to NGF
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