Multiple Roles of the p75 Neurotrophin Receptor in the Nervous System

@article{Chen2009MultipleRO,
  title={Multiple Roles of the p75 Neurotrophin Receptor in the Nervous System},
  author={Y X Chen and Jican Zeng and X. Wang and Guanfeng Yao and W. Wang and Wei-Feng Qi and Kyung Yup Kong},
  journal={Journal of International Medical Research},
  year={2009},
  volume={37},
  pages={281 - 288}
}
  • Y. Chen, J. Zeng, K. Kong
  • Published 1 March 2009
  • Biology
  • Journal of International Medical Research
The p75 neurotrophin receptor (p75NTR) is a transmembrane protein that binds nerve growth factor (NGF) and has multiple functions in the nervous system where it is expressed widely during the developmental stages of life, although expression decreases dramatically by adulthood. Expression of p75NTR can increase in pathological states related to neural cell death. p75NTR is a member of the tumour necrosis factor (TNF) receptor family and it consists of intracellular, transmembrane and… 
View on SAGE
journals.sagepub.com
79 Citations
Highly Influential Citations
6
Background Citations
46

79 Citations

p75 neurotrophin receptor mediates apoptosis in transit-amplifying cells and its overexpression restores cell death in psoriatic keratinocytes
p75 neurotrophin receptor (p75NTR) belongs to the TNF-receptor superfamily and signals apoptosis in many cell settings. In human epidermis, p75NTR is mostly confined to the transit-amplifying (TA)…
TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor
TLDR
It is demonstrated that loss of p75NTR contributes to the neurological phenotype of p73 knockout mice, and at least some of these morphological and functional impairments in p73 null cells can be rescued by p 75NTR re-expression.
High-affinity TrkA and p75 neurotrophin receptor complexes: A twisted affair
Growth and Neurotrophic Factor Receptors in Neural Differentiation and Phenotype Specification
Mapping of neurotrophins and their receptors in the adult mouse brain and their role in the pathogenesis of a transgenic murine model of bovine spongiform encephalopathy.
Role of p75 neurotrophin receptor in stem cell biology: more than just a marker
TLDR
P75NTR-mediated functions include survival, apoptosis, migration, and differentiation, and depend on cell type, (pro)neurotrophin binding, interacting transmembrane co-receptors expression, intracellular adaptor molecule availability, and post-translational modifications, such as regulated proteolytic processing.
Polyubiquitination of the neurotrophin receptor p75 directs neuronal cell survival.
Expression and function of APRIL and GDF-5 in the developing hippocampus
TLDR
The findings reveal that APRIL selectively enhances axon growth from developing hippocampal pyramidal neurons by a mechanism that depends on BCMA and activation of ERK1/2 and Akt/GSK-3β signalling.
The role of brain-derived neurotrophic factor in the regulation of cell growth and gene expression in melanotrope cells of Xenopus laevis.
Schwann cell apoptosis and p75(NTR) siRNA.
The p75 pan-neurotrophin receptor (p75(NTR)) plays a pivotal role in linking the immune system with the nervous system. p75(NTR) is required for the development of several characteristic features of…
...
...

References

SHOWING 1-10 OF 55 REFERENCES
The neurotrophin receptor p75NTR: novel functions and implications for diseases of the nervous system
TLDR
The p75 neurotrophin receptor (p75NTR), a member of the tumor necrosis factor receptor superfamily, associates with the Nogo receptor, a binding protein for axonal growth inhibitors, and appears to be the transducing subunit of this receptor complex.
Induction of cell death by endogenous nerve growth factor through its p75 receptor
TLDR
The results indicate that, as with cells of the immune system, the death of neurons in the central nervous system can also be induced by ligands, and that the effect of NGF on cell fate depends on the type of receptor expressed by developing neurons.
The p75 neurotrophin receptor and neuronal apoptosis
p75 Neurotrophin Receptor Expression on Adult Human Oligodendrocytes: Signaling without Cell Death in Response to NGF
TLDR
These findings contrast with the recent report of NGF-mediated apoptosis in the OLs of neonatal rats matured in vitro, and suggest that, at least in humans, p75NTRsignaling may mediate responses other than apoptosis of OLs.
Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
TLDR
Results indicate that NGF has the ability to promote cell death in specific cell types through a ligand-dependent signalling mechanism involving the p75 neurotrophin receptor.
Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival
TLDR
Results indicate that TrkA-mediated rescue involves not only activation of survival signals but also simultaneous suppression of a death signal by p75, a novel mechanism that achieves alternative cellular responses by merging signals from different ligand–receptor systems.
Structure of Nerve Growth Factor Complexed with the Shared Neurotrophin Receptor p75
TLDR
Neurotrophin signaling through p75 may occur by disassembly of p75 dimers and assembly of asymmetric 2:1 neurotrophin/p75 complexes, which could potentially engage a Trk receptor to form a trimolecular signaling complex.
Individual and Combined Effects of TrkA and p75NTR Nerve Growth Factor Receptors
TLDR
Two unique functions are suggested for the high affinity heteromeric NGF receptor site: integration of both the MAPK and Akt pathways in the production of NGF-induced neurite outgrowth, and rapid and sustained activation of the Akt pathway, with consequent long term cellular survival.
Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75
Neurotrophin Signaling through the p75 Receptor Is Deficient in traf6-/- Mice
TLDR
TRAF6 plays an essential role in mediating p75 signal transduction and induction of apoptosis, and deficiencies in p75 signaling in traf6-/- animals resulted in a loss of p75-mediated apoptosis.
...
...