Multiple Roles of the p75 Neurotrophin Receptor in the Nervous System

@article{Chen2009MultipleRO,
  title={Multiple Roles of the p75 Neurotrophin Receptor in the Nervous System},
  author={Y X Chen and Jican Zeng and X. Wang and Guanfeng Yao and W. Wang and Wei-Feng Qi and Kyung Yup Kong},
  journal={Journal of International Medical Research},
  year={2009},
  volume={37},
  pages={281 - 288}
}
  • Y. Chen, J. Zeng, K. Kong
  • Published 1 March 2009
  • Biology
  • Journal of International Medical Research
The p75 neurotrophin receptor (p75NTR) is a transmembrane protein that binds nerve growth factor (NGF) and has multiple functions in the nervous system where it is expressed widely during the developmental stages of life, although expression decreases dramatically by adulthood. Expression of p75NTR can increase in pathological states related to neural cell death. p75NTR is a member of the tumour necrosis factor (TNF) receptor family and it consists of intracellular, transmembrane and… 
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References

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TLDR
The p75 neurotrophin receptor (p75NTR), a member of the tumor necrosis factor receptor superfamily, associates with the Nogo receptor, a binding protein for axonal growth inhibitors, and appears to be the transducing subunit of this receptor complex.
Induction of cell death by endogenous nerve growth factor through its p75 receptor
TLDR
The results indicate that, as with cells of the immune system, the death of neurons in the central nervous system can also be induced by ligands, and that the effect of NGF on cell fate depends on the type of receptor expressed by developing neurons.
The p75 neurotrophin receptor and neuronal apoptosis
p75 Neurotrophin Receptor Expression on Adult Human Oligodendrocytes: Signaling without Cell Death in Response to NGF
TLDR
These findings contrast with the recent report of NGF-mediated apoptosis in the OLs of neonatal rats matured in vitro, and suggest that, at least in humans, p75NTRsignaling may mediate responses other than apoptosis of OLs.
Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
TLDR
Results indicate that NGF has the ability to promote cell death in specific cell types through a ligand-dependent signalling mechanism involving the p75 neurotrophin receptor.
Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival
TLDR
Results indicate that TrkA-mediated rescue involves not only activation of survival signals but also simultaneous suppression of a death signal by p75, a novel mechanism that achieves alternative cellular responses by merging signals from different ligand–receptor systems.
Structure of Nerve Growth Factor Complexed with the Shared Neurotrophin Receptor p75
TLDR
Neurotrophin signaling through p75 may occur by disassembly of p75 dimers and assembly of asymmetric 2:1 neurotrophin/p75 complexes, which could potentially engage a Trk receptor to form a trimolecular signaling complex.
Individual and Combined Effects of TrkA and p75NTR Nerve Growth Factor Receptors
TLDR
Two unique functions are suggested for the high affinity heteromeric NGF receptor site: integration of both the MAPK and Akt pathways in the production of NGF-induced neurite outgrowth, and rapid and sustained activation of the Akt pathway, with consequent long term cellular survival.
Neurotrophin Signaling through the p75 Receptor Is Deficient in traf6-/- Mice
TLDR
TRAF6 plays an essential role in mediating p75 signal transduction and induction of apoptosis, and deficiencies in p75 signaling in traf6-/- animals resulted in a loss of p75-mediated apoptosis.
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