Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer.

@article{Zhang2017MultipleRO,
  title={Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer.},
  author={Lu Zhang and Jerry W Shay},
  journal={Journal of the National Cancer Institute},
  year={2017},
  volume={109 8}
}
Adenomatous polyposis coli (APC) is widely accepted as a tumor suppressor gene highly mutated in colorectal cancers (CRC). Mutation and inactivation of this gene is a key and early event almost uniquely observed in colorectal tumorigenesis. Alterations in the APC gene generate truncated gene products, leading to activation of the Wnt signaling pathway and deregulation of multiple other cellular processes. It has been a mystery why most patients with CRC retain a truncated APC protein, but… CONTINUE READING