Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer.


Adenomatous polyposis coli (APC) is widely accepted as a tumor suppressor gene highly mutated in colorectal cancers (CRC). Mutation and inactivation of this gene is a key and early event almost uniquely observed in colorectal tumorigenesis. Alterations in the APC gene generate truncated gene products, leading to activation of the Wnt signaling pathway and… (More)
DOI: 10.1093/jnci/djw332