Multiple RRMs contribute to RNA binding specificity and affinity for polypyrimidine tract binding protein.

@article{Prez1997MultipleRC,
  title={Multiple RRMs contribute to RNA binding specificity and affinity for polypyrimidine tract binding protein.},
  author={Ismael P{\'e}rez and J G McAfee and James G Patton},
  journal={Biochemistry},
  year={1997},
  volume={36 39},
  pages={11881-90}
}
Polypyrimidine tract binding protein (PTB) is a 57 kD hnRNP protein (hnRNP I) that binds to the pyrimidine tract typically found near the 3' end of introns. Primary sequence analysis suggests that PTB contains four RNA recognition motifs (RRMs). Data from comparative structural and deletional analysis of PTB are consistent with the presence of a four reiterated domain structure. Since PTB exists in solution as a homodimer, it contains an oligomeric array of eight RRMs. Though the function of… CONTINUE READING