Multiple QTLs influence variation in paraoxonase 1 activity in Mexican Americans.

@article{Winnier2006MultipleQI,
  title={Multiple QTLs influence variation in paraoxonase 1 activity in Mexican Americans.},
  author={Deidre A. Winnier and David Landry Rainwater and S. A. Cole and Thomas D. Dyer and John Blangero and Jean W Maccluer and Michael C. Mahaney},
  journal={Human biology},
  year={2006},
  volume={78 3},
  pages={341-52}
}
Paraoxonase 1 (PON1), a high-density-lipoprotein-associated enzyme known to protect against cellular damage from toxic agents, may also have antioxidant properties. Although the importance of the influence of the PON1 structural locus on chromosome 7q21-22 for variation in the concentration and activity of the enzyme is well-documented, the contribution of other loci is poorly understood. Based on the recent observations of at least one additional quantitative trait locus (QTL) for PON1… CONTINUE READING