Multiple Protein Phosphatases Are Required for Mitosis in Drosophila

  title={Multiple Protein Phosphatases Are Required for Mitosis in Drosophila},
  author={Feng Chen and Vincent Archambault and Ashok J Kar and Pietro Lio' and Pier Paolo D'Avino and Rita Sinka and Kathryn S. Lilley and Ernest D. Laue and P{\'e}ter De{\'a}k and Luisa Capalbo and David M Glover},
  journal={Current Biology},
BACKGROUND Approximately one-third of the Drosophila kinome has been ascribed some cell-cycle function. However, little is known about which of its 117 protein phosphatases (PPs) or subunits have counteracting roles. RESULTS We investigated mitotic roles of PPs through systematic RNAi. We found that G(2)-M progression requires Puckered, the JNK MAP-kinase… CONTINUE READING