Multiple Pharmacophore Models Combined with Molecular Docking: A Reliable Way for Efficiently Identifying Novel PDE4 Inhibitors with High Structural Diversity

Abstract

Multiple pharmacophore models were constructed based on the 18 crystal structures of phosphodiesterase 4 (PDE4) in complex with different inhibitors for discovering new potential PDE4 inhibitors. After validation of their efficiency in screening, 10 of the pharmacophore models were confirmed effective. Remarkably, the hits retrieved by these effective… (More)
DOI: 10.1021/ci9004173

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Cite this paper

@article{Chen2010MultiplePM, title={Multiple Pharmacophore Models Combined with Molecular Docking: A Reliable Way for Efficiently Identifying Novel PDE4 Inhibitors with High Structural Diversity}, author={Zhi Chen and Guanghui Tian and Zhen Wang and Hualiang Jiang and Jingshan Shen and Weiliang Zhu}, journal={Journal of chemical information and modeling}, year={2010}, volume={50 4}, pages={615-25} }