Multiple Peptides Converge to Activate the Same Voltage-Dependent Current in a Central Pattern-Generating Circuit

@article{Swensen2000MultiplePC,
  title={Multiple Peptides Converge to Activate the Same Voltage-Dependent Current in a Central Pattern-Generating Circuit},
  author={A. Swensen and E. Marder},
  journal={The Journal of Neuroscience},
  year={2000},
  volume={20},
  pages={6752 - 6759}
}
The stomatogastric ganglion of the crab, Cancer borealis, is modulated by >20 different substances, including numerous neuropeptides. One of these peptides, proctolin, activates an inward current that shows strong outward rectification (Golowasch and Marder, 1992). Decreasing the extracellular Ca2+concentration linearizes the current–voltage curve of the proctolin-induced current. We used voltage clamp to study the currents evoked by proctolin and five additional modulators [C. borealis… Expand
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Six neuromodulators converge onto the same voltage-dependent inward current in stomatogastric ganglion neurons of the crab C. borealis, and it is shown here that each of these modulators acts on a distinct subset of pyloric network neurons in the STG. Expand
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