Multiple Pathways Control the Reactivation of Telomerase in HTLV-I-Associated Leukemia.

@article{Bellon2015MultiplePC,
  title={Multiple Pathways Control the Reactivation of Telomerase in HTLV-I-Associated Leukemia.},
  author={Marcia Bellon and Christophe Nicot},
  journal={International journal of cancer and oncology},
  year={2015},
  volume={2 2}
}
While telomerase (hTERT) activity is absent from normal somatic cells, reactivation of hTERT expression is a hallmark of cancer cells. Telomerase activity is required for avoiding replicative senescence and supports immortalization of cellular proliferation. Only a minority of cancer cells rely on a telomerase-independent process known as alternative lengthening of telomeres, ALT, to sustain cancer cell proliferation. Multiple genetic, epigenetic, and viral mechanisms have been found to de… CONTINUE READING
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