Multiple Parallel Pathways of Translation Initiation on the CrPV IRES.

@article{Petrov2016MultiplePP,
  title={Multiple Parallel Pathways of Translation Initiation on the CrPV IRES.},
  author={Alexey N. Petrov and Rosslyn Grosely and Jin Chen and Se{\'a}n E O'Leary and Joseph D. Puglisi},
  journal={Molecular cell},
  year={2016},
  volume={62 1},
  pages={92-103}
}
The complexity of eukaryotic translation allows fine-tuned regulation of protein synthesis. Viruses use internal ribosome entry sites (IRESs) to minimize or, like the CrPV IRES, eliminate the need for initiation factors. Here, by exploiting the CrPV IRES, we observed the entire process of initiation and transition to elongation in real time. We directly tracked the CrPV IRES, 40S and 60S ribosomal subunits, and tRNA using single-molecule fluorescence spectroscopy and identified multiple… CONTINUE READING
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