Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery

@article{Chootip2005MultiplePR,
  title={Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery},
  author={Krongkarn Chootip and Alison M Gurney and Charles Kennedy},
  journal={Respiratory Research},
  year={2005},
  volume={6},
  pages={124 - 124}
}
BACKGROUND Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors. Pharmacological characterisation of these receptors in intact arteries is complicated by release and extracellular metabolism of nucleotides, so the aim of this study was to characterise the P2Y receptors under conditions that minimise these problems. METHODS The perforated-patch… CONTINUE READING

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