Multiple Mechanisms of Ketamine Blockade of N‐methyl‐D‐aspartate Receptors

@article{Orser1997MultipleMO,
  title={Multiple Mechanisms of Ketamine Blockade of N‐methyl‐D‐aspartate Receptors},
  author={B. Orser and P. Pennefather and J. Macdonald},
  journal={Anesthesiology},
  year={1997},
  volume={86},
  pages={903–917}
}
  • B. Orser, P. Pennefather, J. Macdonald
  • Published 1997
  • Medicine
  • Anesthesiology
    • Background: The N‐methyl‐D‐aspartate (NMDA) subtype of glutamate receptor is blocked by ketamine, and this action likely contributes to ketamine's anesthetic and analgesic properties. Previous studies suggest that ketamine occludes the open channel by binding to a site located within the channel pore. This hypothesis was examined by investigating the effects of ketamine on single‐channel currents from NMDA receptors. Methods: The cell‐attached and outside‐out configurations of the patch clamp… CONTINUE READING
    View on Wolters Kluwer
    ncbi.nlm.nih.gov
    272 Citations
    Highly Influential Citations
    7
    Background Citations
    105
    Methods Citations
    6
    Results Citations
    1
    272 Citations
    Citation Type

    Citation Type

    Hydroxynorketamine Blocks N-Methyl-d-Aspartate Receptor Currents by Binding to Closed Receptors
    Does Anesthetic Additivity Imply a Similar Molecular Mechanism of Anesthetic Action at N-Methyl-D-Aspartate Receptors?
    • 6
    Ketamine Action in the In Vitro Cortical Slice Is Mitigated by Potassium Channel Blockade
    • 3
    Effect of thiopental sodium on N-methyl-D-aspartate-gated currents
    • 10
    • PDF
    Indistinguishable Synaptic Pharmacodynamics of the N-Methyl-d-Aspartate Receptor Channel Blockers Memantine and Ketamine
    • 44
    • PDF
    Ketamine Increases the Function of &ggr;-Aminobutyric Acid Type A Receptors in Hippocampal and Cortical Neurons
    • 29
    The novel NMDA receptor antagonist, 2‐hydroxy‐5‐(2,3,5,6‐tetrafluoro‐4‐trifluoromethyl‐benzylamino)‐benzoic acid, is a gating modifier in cultured mouse cortical neurons
    • 6
    A Review of the Mechanism of Antagonism of N-methyl-D-aspartate Receptor by Ketamine in Treatment-resistant Depression
    • 15
    • PDF
    Effect of ketamine on voltage-gated potassium channels in rat primary sensory cortex pyramidal neurons
    Effects of ifenprodil on voltage‐gated tetrodotoxin‐resistant Na+ channels in rat sensory neurons
    • 6

    References

    SHOWING 1-10 OF 60 REFERENCES
    Actions of ketamine, phencyclidine and MK‐801 on NMDA receptor currents in cultured mouse hippocampal neurones.
    • 238
    Regulation of N‐methyl‐D‐aspartate receptors revealed by intracellular dialysis of murine neurones in culture.
    • 219
    Activation of N‐methyl‐D‐aspartate receptors by L‐glutamate in cells dissociated from adult rat hippocampus.
    • 181
    Ethanol potentiates and blocks NMDA‐activated single‐channel currents in rat hippocampal pyramidal cells
    • 211
    Ketamine Decreases the Open Time of Single‐channel Currents Activated by Acetylcholine
    • 42
    Phencyclidine and some of its analogues have distinct effects on NMDA receptors of rat hippocampal neurons
    • 11
    A kinetic analysis of the modulation of N‐methyl‐D‐aspartic acid receptors by glycine in mouse cultured hippocampal neurones.
    • 200
    Sites of antagonist action on N-methyl-D-aspartic acid receptors studied using fluctuation analysis and a rapid perfusion technique.
    • 119
    Ketamine-induced anesthesia involves the N-methyl-d-aspartate receptor-channel complex in mice
    • 134
    Whole cell and single channel analysis of the kinetics of glycine‐sensitive N‐methyl‐D‐aspartate receptor desensitization
    • 41