Multiple Mechanisms of Ketamine Blockade of N‐methyl‐D‐aspartate Receptors

@article{Orser1997MultipleMO,
  title={Multiple Mechanisms of Ketamine Blockade of N‐methyl‐D‐aspartate Receptors},
  author={Beverley A. Orser and Peter S. Pennefather and John F. Macdonald},
  journal={Anesthesiology},
  year={1997},
  volume={86},
  pages={903–917}
}
Background: The N‐methyl‐D‐aspartate (NMDA) subtype of glutamate receptor is blocked by ketamine, and this action likely contributes to ketamine's anesthetic and analgesic properties. Previous studies suggest that ketamine occludes the open channel by binding to a site located within the channel pore. This hypothesis was examined by investigating the effects of ketamine on single‐channel currents from NMDA receptors. Methods: The cell‐attached and outside‐out configurations of the patch clamp… 
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