Multiple Machine Learning Based-Chemoinformatics Models for Identification of Histone Acetyl Transferase Inhibitors.

@article{Krishna2018MultipleML,
  title={Multiple Machine Learning Based-Chemoinformatics Models for Identification of Histone Acetyl Transferase Inhibitors.},
  author={Shagun Krishna and Sushil Kumar and Deependra Kumar Singh and Amar Deep Lakra and Dibyendu Banerjee and Mohammad Imran Siddiqi},
  journal={Molecular informatics},
  year={2018}
}
The histone acetyl transferase (HAT) are involved in acetylation of histones that lead to transcription activation in numerous gene regulatory mechanisms. There are very few GCN5 HAT inhibitors reported despite of their role in cancer progression. In this study, we have utilized in-silico virtual screening approaches based on various machine learning… CONTINUE READING