Multiple Lines of Evidence Indicate That Gliotransmission Does Not Occur under Physiological Conditions.

@article{Fiacco2018MultipleLO,
  title={Multiple Lines of Evidence Indicate That Gliotransmission Does Not Occur under Physiological Conditions.},
  author={Todd A Fiacco and Ken D. McCarthy},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2018},
  volume={38 1},
  pages={
          3-13
        }
}
A major controversy persists within the field of glial biology concerning whether or not, under physiological conditions, neuronal activity leads to Ca2+-dependent release of neurotransmitters from astrocytes, a phenomenon known as gliotransmission. Our perspective is that, while we and others can apply techniques to cause gliotransmission, there is considerable evidence gathered using astrocyte-specific and more physiological approaches which suggests that gliotransmission is a pharmacological… CONTINUE READING
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