Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaques.

@article{Chaichompoo2010MultipleKG,
  title={Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaques.},
  author={Porntip Chaichompoo and Pavel Bo{\vs}t{\'i}k and Susan Stephenson and Suthiphol Udompunturuk and Jaruda Kobkitjaroen and Kovit Pattanapanyasat and Aftab A Ansari},
  journal={Cellular immunology},
  year={2010},
  volume={263 2},
  pages={176-87}
}
Innate immune mechanisms play a deterministic role in the rate of disease progression during acute infection in HIV infected humans and SIV infection of non-human primates. The role NK cells play in mediating such an effect has thus gained importance. One of the major sets of molecules that regulate NK cell function are the killer cell immunoglobulin-like molecules (KIR's). Our laboratory has previously shown an association of KIR3DL alleles 13 and 14 with high plasma viral loads in a cohort of… CONTINUE READING

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