Multiple Host Barriers Restrict Poliovirus Trafficking in Mice

  title={Multiple Host Barriers Restrict Poliovirus Trafficking in Mice},
  author={Sharon K. Kuss and Chris A. Etheredge and Julie K Pfeiffer},
  journal={PLoS Pathogens},
  pages={151 - 178}
RNA viruses such as poliovirus have high mutation rates, and a diverse viral population is likely required for full virulence. We previously identified limitations on poliovirus spread after peripheral injection of mice expressing the human poliovirus receptor (PVR), and we hypothesized that the host interferon response may contribute to the viral bottlenecks. Here, we examined poliovirus population bottlenecks in PVR mice and in PVR mice that lack the interferon alpha/beta receptor (PVR-IFNAR… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 55 references

Enteroviruses: poliovirus, coxsackieviruses, echoviruses, and newer enteroviruses

MA Pallansch, RP Roos
Fields BN, et al., eds. Virology • 2001
View 12 Excerpts
Highly Influenced

Mechanism of injury-provoked poliomyelitis.

Journal of virology • 1998
View 13 Excerpts
Highly Influenced

Poliomyelitis and poliovirus immunization. In: Rotbart HA, ed. Human enterovirus infections

JF Modlin
American Society for Microbiology • 1995
View 12 Excerpts
Highly Influenced

Evolution of the Oral Polio Vaccine Strains in Humans Occurs by Both Mutation and Intramolecular Recombination

O Kew, B Nottay
Cold Spring Harbor: Cold Spring Harbor Laboratory • 1984
View 3 Excerpts
Highly Influenced

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