Multiple Functional Variants in cis Modulate PDYN Expression.

  title={Multiple Functional Variants in cis Modulate PDYN Expression.},
  author={Courtney C. Babbitt and Jesse S Silverman and Ralph Clarke Haygood and Jennifer M Reininga and Matthew V Rockman and Gregory A. Wray},
  journal={Molecular biology and evolution},
  volume={27 2},
Understanding genetic variation and its functional consequences within cis-regulatory regions remains an important challenge in human genetics and evolution. Here, we present a fine-scale functional analysis of segregating variation within the cis-regulatory region of prodynorphin, a gene that encodes an endogenous opioid precursor with roles in cognition and disease. In order to characterize the functional consequences of segregating variation in cis in a region under balancing selection in… CONTINUE READING
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Expression of tandem gene duplicates is often greater than twofold.

Proceedings of the National Academy of Sciences of the United States of America • 2016

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