Multiple Forms of Glutamate Dehydrogenase in Animals: Structural Determinants and Physiological Implications

@inproceedings{Bunik2016MultipleFO,
  title={Multiple Forms of Glutamate Dehydrogenase in Animals: Structural Determinants and Physiological Implications},
  author={Victoria I. Bunik and Artem Artiukhov and Vasily Aleshin and Garik Mkrtchyan},
  booktitle={Biology},
  year={2016}
}
Glutamate dehydrogenase (GDH) of animal cells is usually considered to be a mitochondrial enzyme. However, this enzyme has recently been reported to be also present in nucleus, endoplasmic reticulum and lysosomes. These extramitochondrial localizations are associated with moonlighting functions of GDH, which include acting as a serine protease or an ATP-dependent tubulin-binding protein. Here, we review the published data on kinetics and localization of multiple forms of animal GDH taking into… CONTINUE READING
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