Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice

  title={Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice},
  author={Hyunjung Lim and Bibhash C. Paria and Sanjoy Kumar Das and Joseph E. Dinchuk and Robert I Langenbach and James M. Trzaskos and Sudhansu K Dey},
Cyclooxygenase (COX) is the rate-limiting enzyme in the synthesis of prostaglandins (PGs) and exists in two isoforms, COX-1 and COX-2. In spite of long-standing speculation, definitive roles of PGs in various events of early pregnancy remain elusive. We demonstrate herein that the targeted disruption of COX-2, but not COX-1, in mice produces multiple failures in female reproductive processes that include ovulation, fertilization, implantation, and decidualization. Using multiple approaches, we… CONTINUE READING
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