Multiple Epstein-Barr virus strains in patients with infectious mononucleosis: comparison of ex vivo samples with in vitro isolates by use of heteroduplex tracking assays.

@article{Tierney2006MultipleEV,
  title={Multiple Epstein-Barr virus strains in patients with infectious mononucleosis: comparison of ex vivo samples with in vitro isolates by use of heteroduplex tracking assays.},
  author={Rosemary J. Tierney and Rachel Hood Edwards and Diane Sitki-Green and Deborah Croom-Carter and Sushmita Roy and Qing-yun Yao and Nancy Raab-Traub and Alan B. Rickinson},
  journal={The Journal of infectious diseases},
  year={2006},
  volume={193 2},
  pages={287-97}
}
Recent work using a heteroduplex tracking assay (HTA) to identify resident viral sequences has suggested that patients with infectious mononucleosis (IM) who are undergoing primary Epstein-Barr virus (EBV) infection frequently harbor different EBV strains. Here, we examine samples from patients with IM by use of a new Epstein-Barr nuclear antigen 2 HTA alongside the established latent membrane protein 1 HTA. Coresident allelic sequences were detected in ex vivo blood and throat wash samples… CONTINUE READING