Multiple Ebola Virus Transmission Events and Rapid Decline of Central African Wildlife

@article{Leroy2004MultipleEV,
  title={Multiple Ebola Virus Transmission Events and Rapid Decline of Central African Wildlife},
  author={Eric M. Leroy and Pierre Rouquet and Pierre B H Formenty and Sandrine Souquière and Annelisa Kilbourne and Jean-Marc Froment and Magdalena Bermejo and Sheilagh Brigitte Smit and William B. Karesh and Robert Swanepoel and Sherif R Zaki and Pierre E Rollin},
  journal={Science},
  year={2004},
  volume={303},
  pages={387 - 390}
}
Several human and animal Ebola outbreaks have occurred over the past 4 years in Gabon and the Republic of Congo. The human outbreaks consisted of multiple simultaneous epidemics caused by different viral strains, and each epidemic resulted from the handling of a distinct gorilla, chimpanzee, or duiker carcass. These animal populations declined markedly during human Ebola outbreaks, apparently as a result of Ebola infection. Recovered carcasses were infected by a variety of Ebola strains… Expand
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References

SHOWING 1-10 OF 14 REFERENCES
Isolation and partial characterisation of a new strain of Ebola virus
TLDR
A new strain of Ebola virus is isolated from a non-fatal human case infected during the autopsy of a wild chimpanzee in the Côte-d'Ivoire, the first time that a human infection has been connected to naturally-infected monkeys in Africa. Expand
Ebola virus outbreak among wild chimpanzees living in a rain forest of Côte d'Ivoire.
TLDR
Demographic, epidemiologic, and ecologic investigations were compatible with a point-source epidemic, and a high mortality rate among apes tends to indicate that they are not the reservoir for the disease causing the illness. Expand
Persistence and genetic stability of Ebola virus during the outbreak in Kikwit, Democratic Republic of the Congo, 1995.
Ebola virus persistence was examined in body fluids from 12 convalescent patients by virus isolation and reverse transcription-polymerase chain reaction (RT-PCR) during the 1995 Ebola hemorrhagicExpand
Ebola hemorrhagic fever outbreaks in Gabon, 1994-1997: epidemiologic and health control issues.
TLDR
Yellow fever (YF) virus was first diagnosed in serum by use of polymerase chain reaction followed by blotting, and a vaccination campaign was immediately instituted, and EBO virus was found to be present concomitantly with YF virus in the epidemic. Expand
Ebola virus disease in southern Sudan: hospital dissemination and intrafamilial spread.
TLDR
The presence of anti-Ebola antibodies in the sera of 18% of persons who were unassociated with the outbreak suggests that the region is an endemic focus of Ebola virus activity. Expand
The origin and evolution of Ebola and Marburg viruses.
TLDR
The rate of nonsynonymous substitutions for the glycoprotein gene of Ebola virus was estimated to be 3.6 x 10(-5) per site per year, which suggests that purifying selection has operated on Marburg virus during evolution. Expand
Diagnosis of Ebola haemorrhagic fever by RT‐PCR in an epidemic setting
TLDR
RT‐PCR was the most sensitive method and able to detect virus from early acute disease throughout early recovery and specificity compared with antigen detection and IgM assay combined was 97%. Expand
Catastrophic ape decline in western equatorial Africa
TLDR
Survey results conservatively indicate that ape populations in Gabon declined by more than half between 1983 and 2000, and gorillas and common chimpanzees should be elevated immediately to ‘critically endangered’ status. Expand
The reemergence of Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995. Commission de Lutte contre les Epidémies à Kikwit.
TLDR
In May 1995, an international team characterized and contained an outbreak of Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo, and terminated by the initiation of barrier-nursing techniques, health education efforts, and rapid identification of cases. Expand
Sequence analysis of the GP, NP, VP40 and VP24 genes of Ebola virus isolated from deceased, surviving and asymptomatically infected individuals during the 1996 outbreak in Gabon: comparative studies and phylogenetic characterization.
TLDR
The results suggest that the different clinical outcomes of EBOV infection do not result from virus mutations, pointing to divergent evolution of these strains and to selective pressures on this gene. Expand
...
1
2
...