Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models

@inproceedings{Choi2016MultipleDT,
  title={Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models},
  author={Catherine H. Choi and Brian P. Schoenfeld and Aaron J. Bell and Joseph Hinchey and Cory S. Rosenfelt and Michael J. Gertner and Sean R. Campbell and Danielle Emerson and Paul Hinchey and Maria Kollaros and Neal J. Ferrick and Daniel B. Chambers and Steven J Langer and Steven Sust and Aatika Malik and Allison M. Terlizzi and David A. Liebelt and David Fondo Ferreiro and Ali Sharma and Eric Koenigsberg and Richard J. Choi and Natalia Louneva and Steven E Arnold and Robert E. Featherstone and Steven J. Siegel and R Suzanne Zukin and Thomas V McDonald and Francois V Bolduc and Thomas A. Jongens and Sean M Mcbride},
  booktitle={Front. Behav. Neurosci.},
  year={2016}
}
Fragile X is the most common monogenic disorder associated with intellectual disability (ID) and autism spectrum disorders (ASD). Additionally, many patients are afflicted with executive dysfunction, ADHD, seizure disorder and sleep disturbances. Fragile X is caused by loss of FMRP expression, which is encoded by the FMR1 gene. Both the fly and mouse models of fragile X are also based on having no functional protein expression of their respective FMR1 homologs. The fly model displays well… CONTINUE READING
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